The invention relates to modulation of hyaluronic acid (HA) synthesis and degradation. In particular, this invention relates to compositions and methods for modulation of expression of genetic material encoding HA-synthase (HAS) and other enzymes and receptors, primarily involved in the metabolism of hyaluronic acid, or modulation of protein synthesis of hyaluronic acid or degrade including is function lasix drug dose or activity. Songs include or consist of nucleic acid molecules and interactive molecules such as antibodies and small molecule inhibitors and substrate analogues. The present invention also provides for modulation of cell proliferation, it is useful for the prevention and / or treatment of inflammatory diseases, including hiperproliferatyvnyh conditions such as but not limited to, cancer and psoriasis. The present invention relates to compounds, agents, pharmaceutical active substances, drugs, therapy, assets, funds and ... .
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